An Epigenetic Landscape Study: Unraveling the Role of Loss of CCCTC-binding Factor CTCF in Epigenetic Dysregulation in Epstein-Barr Virus-positive Nasopharyngeal Carcinoma

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Grant Data
Project Title
An Epigenetic Landscape Study: Unraveling the Role of Loss of CCCTC-binding Factor CTCF in Epigenetic Dysregulation in Epstein-Barr Virus-positive Nasopharyngeal Carcinoma
Principal Investigator
Professor Dai, Wei   (Principal Investigator (PI))
Co-Investigator(s)
Duration
36
Start Date
2020-01-01
Completion Date
2022-12-31
Amount
1100023
Conference Title
An Epigenetic Landscape Study: Unraveling the Role of Loss of CCCTC-binding Factor CTCF in Epigenetic Dysregulation in Epstein-Barr Virus-positive Nasopharyngeal Carcinoma
Keywords
3D genomics, CTCF, Epigenetic regulation, Multi-omics data integration, Nasopharyngeal carcinoma
Discipline
CancerGenomic Biology
Panel
Biology and Medicine (M)
HKU Project Code
17102619
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 Utilizing the ChIP sequencing to identify the CTCF binding sites and transcriptional active and suppressive histone marks (H3K4me3, H3K27me3, and H3K27ac) in EBV+/- NPC 2 Utilizing the RNA sequencing to examine miRNA profiles and transcriptome data in EBV+/- NPC 3 Utilizing the ChIA-PET sequencing to investigate 3D genomics targeting CTCF binding sites in EBV+/- NPC 4 Integrating the ChIP-Seq, bisulfite sequencing, miRNA and RNA profiling data, and 3D genomics data to characterize cellular and EBV epigenetic landscape in NPC