Towards establishing the structure of antibiotic malacidin A via total synthesis
Grant Data
Project Title
Towards establishing the structure of antibiotic malacidin A via total synthesis
Principal Investigator
Professor Li, Xuechen
(Principal Investigator (PI))
Duration
36
Start Date
2020-01-01
Completion Date
2023-12-28
Amount
558272
Conference Title
Towards establishing the structure of antibiotic malacidin A via total synthesis
Keywords
antibacterial peptide, cyclic peptide, natural product synthesis, peptide ligation
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
17303319
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 Develop a total synthesis of malacidin A 2 Explore HyAsp ligation-mediated peptide cyclization 3 Synthesis of 16 likely diastereomeric forms of malacidin A 4 Establish the absolute structure of malacidin A