Potential implications of Hedgehog-mediated metabolic pathways in neural fate acquisition of human neural crest
Grant Data
Project Title
Potential implications of Hedgehog-mediated metabolic pathways in neural fate acquisition of human neural crest
Principal Investigator
Professor Ngan, Elly Sau Wai
(Principal Investigator (PI))
Duration
42
Start Date
2020-01-01
Completion Date
2023-06-30
Amount
1116019
Conference Title
Potential implications of Hedgehog-mediated metabolic pathways in neural fate acquisition of human neural crest
Keywords
Hedgehog, Hirschsprung, human iPSC, Neural crest
Discipline
Gastroenterology/HepatobiliaryDisease Model Development
Panel
Biology and Medicine (M)
HKU Project Code
17108019
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To define the HH-mediated metabolic pathway(s) favoring the neural fate acquisition of hiPSC-derived ENCCs. 2 To delineate the roles of the non-canonical HH pathway in the neuronal and glial lineage differentiation of hiPSC-derived ENCCs. 3 To decipher the therapeutic potentials of various HH agonists using iPSC-based cell and innervated colonic organoid models of HSCR.