Establishment of a patient-derived organoid in vivo drug testing model in esophageal squamous cell carcinoma and a pilot study for tumor-associated macrophage targeted therapy
Grant Data
Project Title
Establishment of a patient-derived organoid in vivo drug testing model in esophageal squamous cell carcinoma and a pilot study for tumor-associated macrophage targeted therapy
Principal Investigator
Dr Yu, Zhuoyou
(Principal Investigator (PI))
Co-Investigator(s)
Dr Tao Lihua
(Co-Investigator)
Professor Law Simon Ying Kit
(Co-Investigator)
Professor Kwong Dora Lai Wan
(Co-Investigator)
Dr Chan King Chi
(Co-Investigator)
Emeritus Professor Lung Maria Li
(Co-Investigator)
Professor Lam Alfred King-yin
(Co-Investigator)
Duration
36
Start Date
2019-06-01
Amount
1484832
Conference Title
Establishment of a patient-derived organoid in vivo drug testing model in esophageal squamous cell carcinoma and a pilot study for tumor-associated macrophage targeted therapy
Presentation Title
Keywords
carcinoma, esophageal, macrophage, organoid, patient-derived, squamous
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06171566
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
On-going
Objectives
We aim to establish the first panels of esophageal squamous cell carcinoma (ESCC) patient-derived treatment-naïve organoid cultures with a mouse xenograft model for preclinical drug testing. As a pilot study, we plan to explore the feasibility and efficacy of targeting tumor associated macrophages (TAM) to treat ESCC.