The functional significance of RalA: regulations and therapeutic implication in liver cancer
Grant Data
Project Title
The functional significance of RalA: regulations and therapeutic implication in liver cancer
Principal Investigator
Professor Ng, Irene Oi Lin
(Principal Investigator (PI))
Co-Investigator(s)
Dr Chan Lo Kong
(Co-Investigator)
Duration
36
Start Date
2019-06-01
Completion Date
2024-03-26
Amount
1491040
Conference Title
The functional significance of RalA: regulations and therapeutic implication in liver cancer
Keywords
implication, liver, RalA, regulations, significance, therapeutic
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06172886
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
Completed
Objectives
Hepatocellular Carcinoma (HCC) is one of the top lethal cancers in Hong Kong. Effective molecularly targeted therapy against advanced HCC is highly limited. RalA expression is significantly upregulated in HCC tumors, and playing a significant oncogenic role. We aim to uncover the regulatory mechanisms governing RalA dysregulations in terms of expression and activity. Besides, the novel RalA downstream target in the context of HCC will be explored. More importantly, we aim to investigate the therapeutic efficacy of RalA-specific inhibitor in treating HCC using preclinical HCC models.