Establishment of experiment paradigm for defining functional genetic variants and their epistasis contributing to Hirschsprung (HSCR) disease using human pluripotent stem cells (hPSC)

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Grant Data
Project Title
Establishment of experiment paradigm for defining functional genetic variants and their epistasis contributing to Hirschsprung (HSCR) disease using human pluripotent stem cells (hPSC)
Principal Investigator
Professor Ngan, Elly Sau Wai   (Principal Investigator (PI))
Co-Investigator(s)
Duration
36
Start Date
2019-08-15
Amount
1499970
Conference Title
Establishment of experiment paradigm for defining functional genetic variants and their epistasis contributing to Hirschsprung (HSCR) disease using human pluripotent stem cells (hPSC)
Presentation Title
Keywords
epistasis, genetic, Hirschsprung, paradigm, pluripotent, variants
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06173306
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
On-going
Objectives
We aim to establish an experiment paradigm to interconnect SNPs with disease phenotypes and severity, for identification of new diagnostic and/or therapeutic targets for HSCR.