HIV-1 mucosal prevention and immunotherapy by engineered tandem bi-specific IgA
Grant Data
Project Title
HIV-1 mucosal prevention and immunotherapy by engineered tandem bi-specific IgA
Principal Investigator
Professor Chen, Zhiwei
(Principal Investigator (PI))
Duration
36
Start Date
2019-09-16
Amount
1499940
Conference Title
HIV-1 mucosal prevention and immunotherapy by engineered tandem bi-specific IgA
Presentation Title
Keywords
bi-specific, HIV-1, IgA, immunotherapy, mucosal, tandem
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
18170762
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
On-going
Objectives
HIV/AIDS epidemic continues to grow in Hong Kong. To stop AIDS, innovative strategies should be investigated comprehensively for HIV-1 prevention and therapy. We recently reported a tandem bi-specific antibody BiIASG with significantly improved potency, breadth and in vivo efficacy against HIV-1 infection and latency. However, the concentration of BiIA-SG in mucosal secretion is over 100-fold lower than that in blood, suggesting the need of an engineered bi-specific IgA for enhanced mucosal protection.