Arachidonic acid metabolite (15-keto-PGF2α) regulates macrophage M1/M2 polarization against myocardial ischemia reperfusion injury via covalent conjugation with glycolytic enzyme PKM2

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Grant Data
Project Title
Arachidonic acid metabolite (15-keto-PGF2α) regulates macrophage M1/M2 polarization against myocardial ischemia reperfusion injury via covalent conjugation with glycolytic enzyme PKM2
Principal Investigator
Professor Rong, Jianhui   (Principal Investigator (PI))
Co-Investigator(s)
Dr Li Ding   (Co-Investigator)
Dr Zhao Jia   (Co-Investigator)
Professor Tse Hung Fat   (Co-Investigator)
Duration
48
Start Date
2018-01-01
Completion Date
2021-12-31
Amount
816400
Conference Title
Arachidonic acid metabolite (15-keto-PGF2α) regulates macrophage M1/M2 polarization against myocardial ischemia reperfusion injury via covalent conjugation with glycolytic enzyme PKM2
Keywords
15-keto-prostaglandin F2α, arachidonic acid, macrophage polarization, myocardial ischemia-reperfusion injury, pyruvate kinase M2 (PKM2)
Discipline
Traditional Chinese Medicine (basic)Pharmacology/Toxicology
HKU Project Code
21778046
Grant Type
National Natural Science Foundation of China (NSFC) - General Program
Funding Year
2017
Status
Completed
Objectives
1) to study the in vitro and in vivo effects of 15-keto-PGF2α on the polarization and function of macrophages; 2) to characterize the binding of 15-keto-PGF2α to PKM2 and related structural specificity; 3) to determine the in vivo cardioprotective activities of 15-keto-PGF2α against myocardial ischemia reperfusion injury via modulating macrophage polarization.