(4+3) Cycloadditions of Typically Unreactive Aromatic Compounds and Their Applications
Grant Data
Project Title
(4+3) Cycloadditions of Typically Unreactive Aromatic Compounds and Their Applications
Principal Investigator
Professor Chiu, Pauline
(Principal Investigator (PI))
Duration
36
Start Date
2018-09-01
Completion Date
2021-08-31
Amount
505298
Conference Title
(4+3) Cycloadditions of Typically Unreactive Aromatic Compounds and Their Applications
Keywords
benzene, cycloaddition, dearomatization, naphthalene, thiophene
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
17301018
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To study the synthesis of the natural product, tubingensin B by applying the dearomative (4+3) cycloaddition as a key step. 2 To explore the scope and design of substituted benzene and naphthalene (4+3) cycloaddition substrates that would generate dearomatized cycloadducts, which will be applicable for derivatization for the synthesis of non-bridged products. 3 To study and optimize the reaction conditions for intramolecular (4+3) cycloadditions of thiophenes 4 To explore the scope and mechanism of the intramolecular (4+3) cycloadditions of thiophenes 5 To study the derivatizations and reactions of thiophene (4+3) cycloadducts 6 To study the derivatizations and reactions of thiophene (4+3) cycloadducts for the synthesis of non-bridged cycloadducts