Investigation into high γ -aminobutyric acid producing lactic acid bacteria: insights into genomics, and transcriptomics
Grant Data
Project Title
Investigation into high γ -aminobutyric acid producing lactic acid bacteria: insights into genomics, and transcriptomics
Principal Investigator
Professor Yan, Aixin
(Principal Investigator (PI))
Co-Investigator(s)
Professor Jorgensen Erik M.
(Co-Investigator)
Professor Shah Nagendra
(Co-Investigator)
Professor Huang Jiandong
(Co-Investigator)
Duration
42
Start Date
2019-01-01
Completion Date
2022-06-30
Amount
869292
Conference Title
Investigation into high γ -aminobutyric acid producing lactic acid bacteria: insights into genomics, and transcriptomics
Keywords
Anti--hypertensive effect, Lactobacillus brevis, Streptococcus thermophilus, γ-Aminobutyric acid
Discipline
Food ScienceMicrobiology
Panel
Biology and Medicine (M)
HKU Project Code
17103618
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To investigate whether GABA-enriched milk reaches brain tissues as the target organ, and exhibits anti-hypertension effect in rats; 2 To investigate the interactive behavior and microbial physiology at the molecular level using meta-transcriptomic analysis of nutrient uptake between high GABA-producing Lb. brevis and conventional dairy starter, S. thermophilus; 3 To examine the feasibility of manufacturing GABA-rich and MSG-reduced fermented milk by co-culturing high GABA-producing Lb. brevis with S. themophilus with a reduced level of MSG to avoid flavor issues.