Genetic study on the novel roles of vinculin in enteric and cardiac neural crest cell development and the associated congenital diseases
Grant Data
Project Title
Genetic study on the novel roles of vinculin in enteric and cardiac neural crest cell development and the associated congenital diseases
Principal Investigator
Professor Ngan, Elly Sau Wai
(Principal Investigator (PI))
Duration
36
Start Date
2019-01-01
Completion Date
2021-12-31
Amount
972000
Conference Title
Genetic study on the novel roles of vinculin in enteric and cardiac neural crest cell development and the associated congenital diseases
Presentation Title
Keywords
cardiac outflow tract, enteric nervous system, Hirschsprung disease, neural crest, Vinculin
Discipline
Disease Model Development,Gastroenterology/Hepatobiliary
Panel
Biology and Medicine (M)
HKU Project Code
17110818
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To determine how loss of Vcl perturbs ENS development leading to colonic aganglionosis 2 To decipher how Vcl regulates CNCCs in cardiac OFT septation and development of great vessels 3 To delineate the molecular basis of HSCR and VSD using Vcl KO mutants in order to decipher genetic factors underlying these two highly associated diseases for identification of new diagnostic markers