Genomic and Functional Study by Targeting MST1R and Its Related Chromosome 3p21.3 Region Associated with Genetic Susceptibility in Nasopharyngeal Carcinoma

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Grant Data
Project Title
Genomic and Functional Study by Targeting MST1R and Its Related Chromosome 3p21.3 Region Associated with Genetic Susceptibility in Nasopharyngeal Carcinoma
Principal Investigator
Dr Dai, Wei   (Principal Investigator (PI))
Co-Investigator(s)
Duration
36
Start Date
2019-01-01
Completion Date
2021-12-31
Amount
956853
Conference Title
Genomic and Functional Study by Targeting MST1R and Its Related Chromosome 3p21.3 Region Associated with Genetic Susceptibility in Nasopharyngeal Carcinoma
Presentation Title
Keywords
3p21.3 region, cancer genomics, germline mutation, MST1R, nasopharyngeal carcinoma
Discipline
Cancer,Genetics
Panel
Biology and Medicine (M)
HKU Project Code
17103218
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 Validate the association of germline variants in the coding regions of candidate genes with NPC 2 Identify the germline variants in the important regulatory regions and systematically evaluate the association of these variants with NPC 3 Evaluate the clinical significance of the germline variants in association with clinical parameters and outcomes 4 Investigate the somatic alterations of the targeted regions in NPC tumors 5 Determine the functional impact of the selected MST1R germline variants in NPC