Paradoxical vasoconstrictor effect of thymoquinone, a natural product known to induce vasodilatation and used in humans

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Grant Data
Project Title
Paradoxical vasoconstrictor effect of thymoquinone, a natural product known to induce vasodilatation and used in humans
Principal Investigator
Professor Leung, Susan Wai Sum   (Principal Investigator (PI))
Co-Investigator(s)
Professor Leung George Pak Heng   (Co-Investigator)
Duration
42
Start Date
2018-06-01
Completion Date
2024-03-26
Amount
1172600
Conference Title
Paradoxical vasoconstrictor effect of thymoquinone, a natural product known to induce vasodilatation and used in humans
Keywords
cyclic nucleotides, hyperlipidaemia, NAD(P)H:quinone, nitric oxide, soluble guanylyl, thymoquinone
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
15162231
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
Previous experiments indicate that thymoquinone relaxes blood vessels only at relative high concentrations (greater than 10-5 M), but at lower concentrations causes contractions which mask its vasodilator effect. It is hypothesized that thymoquinone may exacerbate vasoconstriction in patients at risk of cardiovascular complications.