Clinical application of enumeration and genomic characterization for non-invasive detection and real-time monitoring of circulating tumor cells for esophageal carcinoma
Grant Data
Project Title
Clinical application of enumeration and genomic characterization for non-invasive detection and real-time monitoring of circulating tumor cells for esophageal carcinoma
Principal Investigator
Emeritus Professor Lung, Maria Li
(Principal Investigator (PI))
Co-Investigator(s)
Professor Kwong Dora Lai Wan
(Co-Investigator)
Dr Dai Wei
(Co-Investigator)
Dr Ko Josephine Mun Yee
(Co-Investigator)
Dr Chiu Wan Hang Keith
(Co-Investigator)
Dr Lam Ka On
(Co-Investigator)
Professor Law Simon Ying Kit
(Co-Investigator)
Dr Chan Kwok Wah
(Co-Investigator)
Duration
24
Start Date
2018-06-01
Amount
1199732
Conference Title
Clinical application of enumeration and genomic characterization for non-invasive detection and real-time monitoring of circulating tumor cells for esophageal carcinoma
Presentation Title
Keywords
biomarker, circulating tumor cell, Drug resistance, esophageal cancer, metastasis, tumor evolution
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
05160926
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
We aim to determine the clinical usefulness of circulating tumor cells (CTCs) as non-invasive real-time monitoring biomarkers for esophageal cancer (EC) at diagnosis, during, and after treatment. NGS analysis of CTCs will be used to determine the clinical utility for identifying genetic alterations as useful predictive biomarkers for metastasis and drug resistance.