Pathological roles of Bromodomain and Extra-Terminal (BET) proteins and their therapeutic implications in liver cancer

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Grant Data
Project Title
Pathological roles of Bromodomain and Extra-Terminal (BET) proteins and their therapeutic implications in liver cancer
Principal Investigator
Dr Wong, Carmen Chak Lui   (Principal Investigator (PI))
Co-Investigator(s)
Dr Wong Chun Ming   (Co-Investigator)
Professor Ng Irene Oi Lin   (Co-Investigator)
Duration
30
Start Date
2018-07-01
Completion Date
2023-02-24
Amount
1198048
Conference Title
Pathological roles of Bromodomain and Extra-Terminal (BET) proteins and their therapeutic implications in liver cancer
Keywords
BRD2, BRD3, BRD4, Bromodomain and, Epigenetics, Hepatocellular Carcinoma
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
05163566
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
Hepatocellular carcinoma (HCC) is the most common and fatal cancer worldwide, and epigenetic regulators are attractive cancer therapeutic targets. In this proposal, we aimed to investigate the prognostic value, functional implications and underlying mechanisms of BET proteins in HCC. We will also explore the potential use of BET protein inhibitor in HCC therapies.