Immune control of SHIV infection in rhesus macaques by PD-1 based vaccine
Grant Data
Project Title
Immune control of SHIV infection in rhesus macaques by PD-1 based vaccine
Principal Investigator
Dr Zhou, Runhong
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chen Zhiwei
(Co-Investigator)
Professor Zhang Haoji
(Co-Investigator)
Duration
24
Start Date
2018-08-01
Amount
1199548
Conference Title
Immune control of SHIV infection in rhesus macaques by PD-1 based vaccine
Presentation Title
Keywords
AIDS, CD8+ T cells, HIV, immunogenicity, vaccine
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
17160762
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
Developing effective vaccines represents one of the solutions for controlling human immunodeficiency virus (HIV). We have developed a novel PD-1-based DNA vaccine against HIV. In a pilot study, it protected rhesus macaques from simianhuman immunodeficiency virus (SHIV) infection. Here we will explore the immune mechanisms how our vaccine induces protection. We will also optimize the vaccine design to improve its efficacy.