Establishing Functional Human Lung Organoids to Recapitulate and Study Viral Growth and Virus-Host Interaction of Avian Influenza A Viruses
Grant Data
Project Title
Establishing Functional Human Lung Organoids to Recapitulate and Study Viral Growth and Virus-Host Interaction of Avian Influenza A Viruses
Principal Investigator
Dr Zhou, Jie
(Principal Investigator (PI))
Co-Investigator(s)
Dr Chu Hin
(Co-Investigator)
Professor Chen Honglin
(Co-Investigator)
Duration
35
Start Date
2018-07-01
Completion Date
2023-10-27
Amount
1200000
Conference Title
Establishing Functional Human Lung Organoids to Recapitulate and Study Viral Growth and Virus-Host Interaction of Avian Influenza A Viruses
Keywords
avian influenza virus, epithelial repair, H5N1, H7N9, lung organoid
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
17161272
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
1.Establish and characterize 2D lung organoids for more effective viral inoculation. 2.Examine viral growth and virus-host interaction of H5H1/H7N9 virus in 2D lung organoids. 3.Delineate regenerative response of basal cells to H5N1/H7N9 virus in 3D organoids and evaluate whether potentiation of β-catenin/FGFR2b signaling pathway can attenuate cytopathogenicity.