Cell-based therapy for congenital myelin disorders of the central nervous system
Grant Data
Project Title
Cell-based therapy for congenital myelin disorders of the central nervous system
Principal Investigator
Professor Shum, Daisy Kwok Yan
(Principal Investigator (PI))
Co-Investigator(s)
Dr Shea Graham Ka Hon
(Co-Investigator)
Dr Tsui Yat Ping
(Co-Investigator)
Professor Chan Ying Shing
(Co-Investigator)
Professor Tu Wenwei
(Co-Investigator)
Duration
36
Start Date
2018-04-01
Amount
1199776
Conference Title
Cell-based therapy for congenital myelin disorders of the central nervous system
Presentation Title
Keywords
Bone marrow stromal, Cell-based therapy, Motor function, Myelin disorder, Oligodendrocyte, Remyelination
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
05163156
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
To develop a cell-based therapy for central nervous system (CNS) myelin disorders through (i) derivation of oligodendrocyte precursors (OPs) from adult human bone marrow stromal cells (hBMSCs), and (ii) evaluation of myelin formation capacity of derived OPs by transplantation into a mouse model of congenital myelin disorder.