AKAP11 as a positive regulator of osteogenesis

Dr Cheung, Ching Lung   (Principal Investigator (PI))

Dr Lui Vivian   (Co-Investigator)

Professor Lu William Weijia   (Co-Investigator)

Professor Tan Kathryn Choon Beng   (Co-Investigator)

24

2018-03-01

1198862

AKAP11 as a positive regulator of osteogenesis

AKAP11, bone mineral density, mineralization, osteogenesis, osteoporosis, sequencing

Others - Medicine, Dentistry and Health

05162796

Health and Medical Research Fund - Full Grant

2017

Completed

Osteoporosis is a prevalent disease characterized by low bone mass and deterioration in microarchitecture and bone strength with a consequent increased risk of fragility fracture. The aetiology of osteoporosis is multifactorial and complex. It has been established that genetic factors play an important role in disease determination. Using a genome-wide association study (GWAS) approach, more than 66 well validated loci have been found to be associated with variation in bone mineral density (BMD). Nonetheless whether rare variants (with frequency<1%), especially nonsynonymous variants, contribute this variation is largely unknown.