Studies on Intramolecular (3+2) Cycloadditions of Epoxy and Aziridinyl Enolsilane Derivatives
Grant Data
Project Title
Studies on Intramolecular (3+2) Cycloadditions of Epoxy and Aziridinyl Enolsilane Derivatives
Principal Investigator
Professor Chiu, Pauline
(Principal Investigator (PI))
Duration
36
Start Date
2017-08-01
Amount
522898
Conference Title
Studies on Intramolecular (3+2) Cycloadditions of Epoxy and Aziridinyl Enolsilane Derivatives
Presentation Title
Keywords
aziridines, cycloaddition, enolsilanes, epoxides, five-membered rings
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
17305017
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To examine the mechanism by computations and experiment, and to optimize the reaction conditions of the (3+2) cycloaddition of epoxy enolsilanes; 2 To study the scope of the two-carbon pi-components for the (3+2) cycloaddition; 3 To investigate the scope of the epoxide and aziridinyl electrophiles for the (3+2) cycloadditions; 4 To explore the range of polycycles that can be formed from this intramolecular cycloaddition by examining the length and nature of the tether; 5 To apply the cycloaddition results to natural product synthesis