Development of amine-specific reactions for peptide/protein modification and bioconjugation
Grant Data
Project Title
Development of amine-specific reactions for peptide/protein modification and bioconjugation
Principal Investigator
Professor Li, Xuechen
(Principal Investigator (PI))
Duration
36
Start Date
2018-01-01
Amount
522898
Conference Title
Development of amine-specific reactions for peptide/protein modification and bioconjugation
Presentation Title
Keywords
bioconjugation, cyclic peptide, lysine reaction, peptide synthesis, protein chemistry
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
17303617
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To develop the versatile synthesis of bi-functional OPA derivatives 2 To explore the structure-activity relationship of OPA derivatives toward the amine reaction and ligand-guided Lys site-specific modification 3 To apply PT ligation in the synthesis of cyclic peptides and bi-cyclic peptides