Understanding hyperplastic callus and abnormal bone formation in osteogenesis imperefecta type V
Grant Data
Project Title
Understanding hyperplastic callus and abnormal bone formation in osteogenesis imperefecta type V
Principal Investigator
Professor Chan, Danny
(Principal Investigator (PI))
Co-Investigator(s)
Dr To Michael Kai Tsun
(Co-Investigator)
Dr Gao Bo
(Co-Investigator)
Duration
36
Start Date
2018-01-01
Amount
959452
Conference Title
Understanding hyperplastic callus and abnormal bone formation in osteogenesis imperefecta type V
Presentation Title
Keywords
Bone formation, bone healing, ectopic ossification, hyperplastic callus formation, osteogenesis imperfecta
Discipline
Cell Biology,Disease Model Development
Panel
Biology and Medicine (M)
HKU Project Code
17128817
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To identify the molecular responses of OI-V osteoblasts driving progression of calcification in vitro 2 To assess the efficacy of OI-V bones to induce calcification of soft tissues in vitro and in vivo 3 To study bone formation and fracture healing in mouse models of OI-V