Regulation of inflammasome activation in systemic lupus erythematosus

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Grant Data
Project Title
Regulation of inflammasome activation in systemic lupus erythematosus
Principal Investigator
Dr Chan, Vera Sau Fong   (Principal Investigator (PI))
Co-Investigator(s)
Professor Lau Wallace Chak Sing   (Co-Investigator)
Professor Shen Nan   (Co-Investigator)
Duration
39
Start Date
2017-10-01
Amount
1229089
Conference Title
Regulation of inflammasome activation in systemic lupus erythematosus
Presentation Title
Keywords
Inflammasomes, microRNA, regulatory mechanism, systemic lupus erythematosus
Discipline
Rheumatology,Allergy/Immunology
Panel
Biology and Medicine (M)
HKU Project Code
17123517
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To fully characterize the dysregulated AIM2 inflammasome response in correlation with SLE disease; 2 To elucidate miRNA regulatory mechanism that contributes to type I IFN mediated AIM2 inflammasome dysregulation in SLE monocytes