Functional role of an interferon-stimulated gene IFIRM in influenza A virus infection
Grant Data
Project Title
Functional role of an interferon-stimulated gene IFIRM in influenza A virus infection
Principal Investigator
Dr Kok, Kin Hang
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chen Honglin
(Co-Investigator)
Duration
36
Start Date
2018-01-01
Amount
1196388
Conference Title
Functional role of an interferon-stimulated gene IFIRM in influenza A virus infection
Presentation Title
Keywords
influenza A virus, innate immune response, interferon-stimulated genes, type-I interferons, virus-host interaction
Discipline
Allergy/Immunology,Infection/Parasitology
Panel
Biology and Medicine (M)
HKU Project Code
17124317
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To examine the functional role of IFIRM during influenza A virus infection 1.1 Generation of tetracycline-inducible IFIRM cells and IFIRM-knockout cells 1.2 Evaluation of the antiviral potential of IFIRM during influenza A virus infection . 2 To dissect the antiviral mechanism of IFIRM during influenza A virus infection 2.1 Determination of the interaction between IFIRM, YTHDF proteins and viral RNA 2.2 Assessment of the regulatory role of IFIRM in viral mRNA translation and/or stability . 3 To determine the physiological role of IFIRM during influenza A virus infection 3.1 Examination of influenza A virus replication in inducible IFIRM transgenic mice 3.2 Evaluation of influenza A virus pathogenicity in inducible IFIRM transgenic mice