A comprehensive study on the effects of antioxidant supplements in liver cancer development and treatment

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Grant Data
Project Title
A comprehensive study on the effects of antioxidant supplements in liver cancer development and treatment
Principal Investigator
Professor Ng, Irene Oi Lin   (Principal Investigator (PI))
Co-Investigator(s)
Dr Wong Carmen Chak Lui   (Co-Investigator)
Duration
24
Start Date
2017-06-01
Amount
1199900
Conference Title
A comprehensive study on the effects of antioxidant supplements in liver cancer development and treatment
Presentation Title
Keywords
antioxidant supplements, Liver cancer, oxidative stress, sorafenib
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
04152336
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2016
Status
Completed
Objectives
Antioxidant supplements have long been advocated as health boosters with anti-cancer power. However, epidemiologic studies have shown inconsistent conclusions, with some even documenting intake of antioxidant supplement would increase cancer risk. Hepatocellular carcinoma (HCC) is one of the leading fatal cancer worldwide and is particularly prevalent in Hong Kong. Emerging studies have shown that HCC cells need even more cellular antioxidants than normal cells. Whether external antioxidants could enhance HCC growth remains elusive. We aim to study the roles of antioxidant supplements in different stages of HCC development.