Investigating the impact of periodontitis on neuroinflammation, neuropathology and neurodegeneration in Alzheimer's disease

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Grant Data
Project Title
Investigating the impact of periodontitis on neuroinflammation, neuropathology and neurodegeneration in Alzheimer's disease
Principal Investigator
Dr Chang, Raymond Chuen Chung   (Principal Investigator (PI))
Co-Investigator(s)
Professor Leung Wai Keung   (Co-Investigator)
Dr Ho Yuen-Shan   (Co-Investigator)
Professor Khong Pek Lan   (Co-Investigator)
Duration
34
Start Date
2017-08-01
Amount
1200000
Conference Title
Investigating the impact of periodontitis on neuroinflammation, neuropathology and neurodegeneration in Alzheimer's disease
Presentation Title
Keywords
Alzheimer's disease, cognitive functions, dementia, neuroinflammation, periodontitis, sickness responses
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
04151216
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2016
Status
Completed
Objectives
To investigate whether and how periodontitis-elicited systemic inflammation affects neuroinflammation and accelerates progression of Alzheimer’s disease (AD) pathology; and whether simply applying antibiotic can attenuate accelerated progression of AD pathology.