Therapeutic potential of targeting CDK7-dependent and super-enhancer associated oncogene addiction in liver cancer
Grant Data
Project Title
Therapeutic potential of targeting CDK7-dependent and super-enhancer associated oncogene addiction in liver cancer
Principal Investigator
Dr Wong, Chun Ming
(Principal Investigator (PI))
Co-Investigator(s)
Professor Ng Irene Oi Lin
(Co-Investigator)
Dr Tsang Felice Hoching
(Co-Investigator)
Duration
30
Start Date
2017-05-01
Amount
962856
Conference Title
Therapeutic potential of targeting CDK7-dependent and super-enhancer associated oncogene addiction in liver cancer
Presentation Title
Keywords
CDK7, Hepatocellular carcinoma, Super-enhancer, THZ1, Transcriptional addiction
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
04150856
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2016
Status
Completed
Objectives
In this proposal, we aim to thoroughly investigate the pathological and functional implications of CDK7 in liver carcinogenesis. We will also evaluate the therapeutic potential of THZ1 in HCC with both in vitro and in vivo models. The complementary effect of THZ1 and Sorafenib combination therapy will be investigated. We believe our proposed study will shed light to the development of novel therapeutic regime for HCC patients.