Integration of new neurons into the mature vestibular circuitry requires GABAergic signaling for relevant outcome in behavior
Grant Data
Project Title
Integration of new neurons into the mature vestibular circuitry requires GABAergic signaling for relevant outcome in behavior
Principal Investigator
Professor Chan, Ying Shing
(Principal Investigator (PI))
Co-Investigator(s)
Dr Lai Sau Wan Cora
(Co-Investigator)
Professor Yung Wing Ho
(Co-Investigator)
Professor Shum Daisy Kwok Yan
(Co-Investigator)
Duration
42
Start Date
2016-07-01
Amount
1049587
Conference Title
Integration of new neurons into the mature vestibular circuitry requires GABAergic signaling for relevant outcome in behavior
Presentation Title
Keywords
Circuitry plasticity, Drug-induced neurogenesis, GABAergic signaling, PV neuron, Spatial navigation
Discipline
Neurobiology and Neuromedicine,Neuroscience
Panel
Biology and Medicine (M)
HKU Project Code
17131816
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To enhance generation of PV neurons with relevant dosing of fluoxetine. 2 To show that plasticity of the vestibular circuit is enhanced by GABA-mediated integration of new PV neurons. 3 To demonstrate spatial navigation as a functional outcome of integration of new PV neurons into the vestibular circuit.