Kinesin family member protein 7 (KIF7) in ciliopathy associated gut motility disorders
Grant Data
Project Title
Kinesin family member protein 7 (KIF7) in ciliopathy associated gut motility disorders
Principal Investigator
Professor Ngan, Elly Sau Wai
(Principal Investigator (PI))
Duration
36
Start Date
2017-01-01
Amount
961033
Conference Title
Kinesin family member protein 7 (KIF7) in ciliopathy associated gut motility disorders
Presentation Title
Keywords
enteric nervous system, Hedgehog, Kif7, neural crest, Sufu
Discipline
Gastroenterology/Hepatobiliary,Disease Model Development
Panel
Biology and Medicine (M)
HKU Project Code
17112416
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To decipher how loss of Kif7 interferes ENS development using conditional Kif7KO mice to define the disease mechanism underlying enteric dysmotility of ciliopathy patients 2 To characterize the gut motility disorder of Kif7KO adult mice in order to establish a model of a complex clinical condition of gut dysmotility for future therapeutic interventions