Development of novel equilibrative nucleoside transporter-2 inhibitor and its application in studying the functions of equilibrative nucleoside transporter-2 in skeletal muscle
Grant Data
Project Title
Development of novel equilibrative nucleoside transporter-2 inhibitor and its application in studying the functions of equilibrative nucleoside transporter-2 in skeletal muscle
Principal Investigator
Dr Leung, George Pak Heng
(Principal Investigator (PI))
Co-Investigator(s)
Professor Kwan Yiu Wa
(Co-Investigator)
Dr Ballard Heather Janet
(Co-Investigator)
Duration
24
Start Date
2016-10-01
Amount
573420
Conference Title
Development of novel equilibrative nucleoside transporter-2 inhibitor and its application in studying the functions of equilibrative nucleoside transporter-2 in skeletal muscle
Presentation Title
Keywords
ENT2, hypoxanthine, purines, reactive oxygen species, Skeletal muscle
Discipline
Pharmacology/Toxicology,Drug Discovery and Delivery
Panel
Biology and Medicine (M)
HKU Project Code
17156016
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 to study the mechanism(s) by which FPMINT inhibits ENT2 2 to study the effects of PFMINT on the levels of purines and reactive oxygen species production in skeletal muscle 3 to study the effects of PFMINT on skeletal muscle microvascular endothelial cells.