Deregulation and pathological implications of RNA N6-adensoine methyltransferase METTL3 in liver carcinogenesis

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Grant Data
Project Title
Deregulation and pathological implications of RNA N6-adensoine methyltransferase METTL3 in liver carcinogenesis
Principal Investigator
Dr Wong, Chun Ming   (Principal Investigator (PI))
Co-Investigator(s)
Professor Ng Irene Oi Lin   (Co-Investigator)
Duration
36
Start Date
2017-03-01
Amount
1131031
Conference Title
Deregulation and pathological implications of RNA N6-adensoine methyltransferase METTL3 in liver carcinogenesis
Presentation Title
Keywords
Epigenetics, Hepatocellular carcinoma, METTL3, N6-adenosine methylation, RNA methylation
Discipline
Cancer,Pathology
Panel
Biology and Medicine (M)
HKU Project Code
17142516
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To determine the expression change of METTL3 and its impacts on global m6A level in human HCC 2 To evaluate the clinicopathological and prognostic significances of METTL3 and m6A deregulation in human HCC 3 To characterize the functions of METTL3 in HCC growth and metastasis with in vitro and in vivo models 4 To elucidate the molecular mechanisms underlying METTL3 mediated liver carcinogenesis