The role of ARRDC3 in the innate immune response to influenza A virus infection

View Statistics Email Alert RSS Feed

Grant Data
Project Title
The role of ARRDC3 in the innate immune response to influenza A virus infection
Principal Investigator
Dr Kok, Kin Hang   (Principal Investigator (PI))
Co-Investigator(s)
Professor Chen Honglin   (Co-Investigator)
Duration
36
Start Date
2017-01-01
Amount
1037690
Conference Title
The role of ARRDC3 in the innate immune response to influenza A virus infection
Presentation Title
Keywords
influenza A virus infection, innate immune response, Interferon stimulated genes, type-I interferons, virus-host interaction
Discipline
Allergy/Immunology,Infection/Parasitology
Panel
Biology and Medicine (M)
HKU Project Code
17153216
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To investigate the functional role of ARRDC3 in the innate immune response 1.1 Generation of ARRDC3 knockout cells 1.2 Role of ARRDC3 in NFκB signaling and inflammasome activation . 2 To dissect the molecular mechanism of ARRDC3 against influenza A virus infection To dissect the molecular mechanism of ARRDC3 against influenza A virus infection 2.1 Characterization of the regulatory role of ARRDC3 in NFκB signaling 2.2 Characterization of the regulatory role of ARRDC3 in influenza A virus infection . 3 To determine the physiological role of ARRDC3 during influenza A virus infection 3.1 Examination of influenza A virus replication in ARRDC3-knockout mice 3.2 Examination of influenza A virus pathogenicity in ARRDC3-knockout mice .