The role of SUMO-specific protease SENP1 in liver cancer

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Grant Data
Project Title
The role of SUMO-specific protease SENP1 in liver cancer
Principal Investigator
Professor Ng, Irene Oi Lin   (Principal Investigator (PI))
Co-Investigator(s)
Dr Wong Carmen Chak Lui   (Co-Investigator)
Dr Cui Chunping   (Co-Investigator)
Duration
42
Start Date
2015-10-01
Amount
1198878
Conference Title
The role of SUMO-specific protease SENP1 in liver cancer
Presentation Title
Keywords
hepatocellular carcinoma, hypoxia, metastasis, SENP1, tumor growth
Discipline
Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17111315
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To evaluate the expression and clinical significance of SENP1 in HCC. 2 To investigate the role of SENP1 on liver cancer stem cells. 3 To characterize the functional roles of SENP1 in HCC. 4 To delineate the molecular mechanisms of SENP1 and its interaction with HIF in HCC.