The functional role of Hsa-miR-141 in metastatic progression of ovarian cancer

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Grant Data
Project Title
The functional role of Hsa-miR-141 in metastatic progression of ovarian cancer
Principal Investigator
Dr Chan, David Wai   (Principal Investigator (PI))
Co-Investigator(s)
Duration
36
Start Date
2015-11-01
Amount
1344714
Conference Title
The functional role of Hsa-miR-141 in metastatic progression of ovarian cancer
Presentation Title
Keywords
Anoikis, omental metastasis, ovarian cancer, secretary miRNAs, tumor microenvironment
Discipline
Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17115115
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To investigate the significance and mechanism of miR-141/KLF12/survivin signaling cascade in intrinsic apoptotic pathway and anoikis resistance of ovarian cancer cells. 2 To study the molecular mechanism of miR-141 in cell-to-cell communication. 3 To investigate the significance and mechanism of cancer-secreted miR-141 in remodeling fibroblast cells and promoting ovarian cancer metastatic colonization.