Role of PD1-Based Vaccine-Elicited CD8+ T Lymphocytes in Modulating MDSC-associated Immunosuppression
Grant Data
Project Title
Role of PD1-Based Vaccine-Elicited CD8+ T Lymphocytes in Modulating MDSC-associated Immunosuppression
Principal Investigator
Professor Chen, Zhiwei
(Principal Investigator (PI))
Co-Investigator(s)
Dr Tan Zhiwu
(Co-Investigator)
Dr Cheung Ka Loon Allen
(Co-Investigator)
Duration
36
Start Date
2016-01-01
Amount
977457
Conference Title
Role of PD1-Based Vaccine-Elicited CD8+ T Lymphocytes in Modulating MDSC-associated Immunosuppression
Presentation Title
Keywords
AIDS, Cure, HIV, T cell, Vaccine
Discipline
Allergy/Immunology
Panel
Biology and Medicine (M)
HKU Project Code
17122915
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To understand the role of PD1-vaccine-elicited CD8+ T cells in modulating MDSC responses (year 1-1.5) We will focus on critical experiments and minimal number of mice due to the budge cut. 2 To enhance the efficacy of vaccine-elicited CD8+ T cells in eliminating HIV-1 infected cells by reducing MDSC responses (year 1.5-3) We will focus on critical experiments and minimal number of mice due to the budge cut.