Functional and Mechanistic Investigation of Frequent p53 Gain-of-Function Mutations in Esophageal Squamous Cell Carcinoma
Grant Data
Project Title
Functional and Mechanistic Investigation of Frequent p53 Gain-of-Function Mutations in Esophageal Squamous Cell Carcinoma
Principal Investigator
Emeritus Professor Lung, Maria Li
(Principal Investigator (PI))
Duration
36
Start Date
2015-09-01
Amount
1168311
Conference Title
Functional and Mechanistic Investigation of Frequent p53 Gain-of-Function Mutations in Esophageal Squamous Cell Carcinoma
Presentation Title
Keywords
esophageal cancer, gain-of-function mutation, metastasis, orthotopic model, p53
Discipline
Cell Biology
Panel
Biology and Medicine (M)
HKU Project Code
17109515
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 Elucidate the function of key ESCC gain-of-function p53 mutants 2 Perform mechanistic and signaling studies of gain-of-function p53 mutants in ESCC