Role of Angiotensin Receptor Blocker to Decrease the Progression of Left Ventricular Remodeling in Patients with Asymptomatic Aortic Stenosis
Grant Data
Project Title
Role of Angiotensin Receptor Blocker to Decrease the Progression of Left Ventricular Remodeling in Patients with Asymptomatic Aortic Stenosis
Principal Investigator
Professor Yiu, Kai Hang
(Principal Investigator (PI))
Co-Investigator(s)
Professor Tse Hung Fat
(Co-Investigator)
Duration
36
Start Date
2016-01-01
Amount
554700
Conference Title
Role of Angiotensin Receptor Blocker to Decrease the Progression of Left Ventricular Remodeling in Patients with Asymptomatic Aortic Stenosis
Presentation Title
Keywords
Angiotensin Receptor Blocker, Aortic Stenosis, Left Ventricular Remodeling
Discipline
Cardiovascular Research
Panel
Biology and Medicine (M)
HKU Project Code
17120715
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To evaluate the relationship between activity of the RAS with myocardial structural alteration (by calibrated IBS), myocardial contractility (by 2D speckle tracking stain analysis), Zva and arterial stiffening (with PWV) in patients with asymptomatic AS. 2 To determine whether blockage of the RAS by ARB for 1 year can slow the progression of LVH in patients with asymptomatic AS.