Humanized mouse as a model to study the antiviral activity of human gammadelta-T cells against human and avian influenza A viruses in vivo

Project Title	Humanized mouse as a model to study the antiviral activity of human gammadelta-T cells against human and avian influenza A viruses in vivo
Principal Investigator	Tu, Wenwei (Principal investigator)
Co-Investigator(s)	Lau, Yu Lung (Co-Investigator) Dr Law Helen Ka Wai (Co-Investigator) Peiris, Joseph Sriyal Malik (Co-Investigator)
Project Code	07060482
Funding Year	2007/2008
Amount	789648
Start Date	01-08-2007
Expected Completion	31-07-2009
Status	On-going
Keywords	innate immunity, influenza virus, gammadelta-T cells, T lymphocyte
Grant Type/Funding Scheme	Research Fund for the Control of Infectious Diseases - Full Grants
Duration	24
Publication	Efficient generation of human alloantigen-specific CD4 + regulatory T cells from naive precursors by CD40-activated B cells
Publication	Phosphoantigen-expanded human γδ T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses
Publication	Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
Publication	The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice
Publication	Phenotypic and functional characterization of human γδT-cell subsets in response to influenza a viruses

Project Title

Principal Investigator

Co-Investigator(s)

Lau, Yu Lung (Co-Investigator)
Dr Law Helen Ka Wai (Co-Investigator)
Peiris, Joseph Sriyal Malik (Co-Investigator)

Project Code

07060482

Funding Year

2007/2008

Amount

789648