| Project Title |
Developmental genomics and skeletal research
|
| Principal Investigator |
Cheah, Kathryn Song Eng
(Principal investigator)
|
| Co-Investigator(s) |
Sham, Mai Har
(Co-principal investigator)
Cheung, Kenneth Man Chee
(Co-principal investigator)
Chan, Danny
(Co-principal investigator)
Huang, Jiandong
(Co-principal investigator)
Jin, Dong-Yan
(Co-principal investigator)
Dr Smith David Keith
(Co-principal investigator)
Sham, Pak Chung
(Co-principal investigator)
Song, You-qiang
(Co-principal investigator)
Shum, Daisy Kwok Yan
(Co-principal investigator)
Luk, Keith Dip Kei
(Co-principal investigator)
|
| Project Code |
|
| Funding Year |
|
| Amount |
|
| Start Date |
|
| Expected Completion |
|
| Status |
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| Keywords |
genomics and skeletal research
|
| Sponsor |
RGC Areas of Excellence (AoE)
|
| Grant Type/Funding Scheme |
Areas of Excellence Scheme
|
| Duration |
|
| Publication |
(iii) Whole-genome association studies of complex diseases
|
| Publication |
(iv) Genetics of disc degeneration
|
| Publication |
A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel NaV1.8
|
| Publication |
The developmental roles of the extracellular matrix: Beyond structure to regulation
|
| Publication |
Increased basal insulin secretion in Pdzd2-deficient mice
|
| Publication |
Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease
|
| Publication |
Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2
|
| Publication |
SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation
|
| Publication |
Nanostructure of collagen fibrils in human nucleus pulposus and its correlation with macroscale tissue mechanics
|
| Publication |
In vivo cellular adaptation to ER stress: Survival strategies with double-edged consequences
|
| Publication |
ISSLS prize winner: Prevalence, determinants, and association of schmorl nodes of the lumbar spine with disc degeneration: A population-based study of 2449 individuals
|
| Publication |
Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signalling
|
| Publication |
Are "patterns" of lumbar disc degeneration associated with low back pain?: New insights based on skipped level disc pathology
|
| Publication |
No NRG1 V266L in Chinese patients with schizophrenia
|
| Publication |
A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas.
|
| Publication |
Intervertebral disc degeneration: New insights based on "skipped" level disc pathology
|
| Publication |
Fine mapping of the 9q31 Hirschsprung's disease locus
|
| Publication |
(ii) Family-based linkage and case control association studies
|
| Publication |
Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women
|
| Publication |
A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range
|
| Publication |
Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression
|
| Publication |
Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush
|
| Publication |
Genome-wide copy number analysis uncovers a new HSCR gene: NRG3
|
| Publication |
Oncogenicity of the developmental transcription factor Sox9
|
