| Project Title |
Institute of molecular technology for drug discovery and synthesis
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| Principal Investigator |
Che, Chi Ming
(Principal investigator)
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| Project Code |
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| Funding Year |
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| Amount |
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| Start Date |
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| Expected Completion |
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| Status |
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| Keywords |
drug discovery and synthesis
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| Sponsor |
RGC Areas of Excellence (AoE)
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| Grant Type/Funding Scheme |
Areas of Excellence Scheme
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| Duration |
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| Publication |
Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats
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| Publication |
Identification and characterization of metallodrug binding proteins by (metallo)proteomics
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| Publication |
Gold(III) (C^N) complex-catalyzed synthesis of propargylamines via a three-component coupling reaction of aldehydes, amines and alkynes
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| Publication |
Cyclometalated platinum(II) complexes as highly sensitive luminescent switch-on probes for practical application in protein staining and cell imaging
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| Publication |
Persistence of camptothecin analog - topoisomerase I - DNA ternary complexes: A molecular dynamics study
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| Publication |
Primary and secondary phosphine complexes of iron porphyrins and ruthenium phthalocyanine: Synthesis, structure, and P-H bond functionalization
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| Publication |
Ion desorption efficiency and internal energy transfer in carbon-based surface-assisted laser desorption/ionization mass spectrometry: Desorption mechanism(s) and the design of SALDI substrates
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| Publication |
Gold(I)-catalyzed intermolecular hydroarylation of alkenes with indoles under thermal and microwave-assisted conditions
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| Publication |
A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine
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| Publication |
Stable anticancer gold(III)-porphyrin complexes: Effects of porphyrin structure
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| Publication |
Stabilization of G-quadruplex DNA with platinum(II) Schiff base complexes: Luminescent probe and down-regulation of c-myc oncogene expression
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| Publication |
Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening
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| Publication |
Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons
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| Publication |
Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
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| Publication |
The rhodium-catalyzed carbene cyclization cycloaddition cascade reaction of vinylsulfonates
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| Publication |
Sinoracutine, a novel skeletal alkaloid with cell-protective effects from Sinomenium acutum
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| Publication |
Graphite-supported gold nanoparticles as efficient catalyst for aerobic oxidation of benzylic amines to imines and N-substituted 1,2,3,4- tetrahydroisoquinolines to amides: Synthetic applications and mechanistic study
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| Publication |
Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis
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| Publication |
Highly enantioselective synthesis of chiral secondary amines by gold(I)/ chiral bronsted acid catalyzed tandem intermodular hydroamination and transfer hydrogenation reactions
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| Publication |
Structure-based discovery of natural-product-like tnf-α inhibitors
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| Publication |
Pseudolaric acids: Isolation, bioactivity and synthetic studies
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| Publication |
Conjugation of latent membrane protein (LMP)-2 epitope to gold nanoparticles as highly immunogenic multiple antigenic peptides for induction of Epstein-Barr virus-specific cytotoxic T-lymphocyte responses in vitro
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| Publication |
Molecular imaging of banknote and questioned document using solvent-free gold nanoparticle-assisted laser desorption/ionization imaging mass spectrometry
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| Publication |
Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes
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| Publication |
Efficient gold(I)-catalyzed direct intramolecular hydroalkylation of unactivated alkenes with α-ketones
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| Publication |
Organoplatinum(II) complexes with nucleobase motifs as inhibitors of human topoisomerase II catalytic activity
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| Publication |
Gold(I)-catalyzed enantioselective intermolecular hydroarylation of allenes with indoles and reaction mechanism by density functional theory calculations
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| Publication |
A selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar silver(I) ions in aqueous solution
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| Publication |
Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons
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| Publication |
"Turn-on" FRET-based luminescent iridium(iii) probes for the detection of cysteine and homocysteine
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| Publication |
A silver-promoted auto-tandem catalysis for the synthesis of multiply substituted tetrahydrocarbazoles
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| Publication |
Osmium(vi) complexes as a new class of potential anti-cancer agents
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| Publication |
Selective functionalisation of saturated C-H bonds with metalloporphyrin catalysts
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| Publication |
Luminescent cyclometalated platinum(II) complexes containing N-heterocyclic carbene ligands with potent in vitro and in vivo anti-cancer properties accumulate in cytoplasmic structures of cancer cells
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| Publication |
[FeIII(F20-tpp)Cl] Is an effective catalyst for nitrene transfer reactions and animation of saturated hydrocarbons with sulfonyl and aryl azides as nitrogen source under thermal and microwave-assisted conditions
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| Publication |
Ruthenium complexes of 1,4,7-trimethyl-1,4,7-triazacyclononane for atom and group transfer reactions
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| Publication |
Ruthenium-porphyrin-catalyzed carbenoid transfer reactions
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| Publication |
Gold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase
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| Publication |
Quinoneimido complexes of a metalloporphyrin: Isolation, X-ray crystal structures, and DFT calculations
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| Publication |
A highly selective FRET-based fluorescent probe for detection of cysteine and homocysteine
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| Publication |
Gold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis
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| Publication |
Anticancer gold(i)-phosphine complexes as potent autophagy-inducing agents
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| Publication |
Chiral copper-bipyridine complexes: Synthesis, characterization and mechanistic studies on asymmetric cyclopropanation
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| Publication |
Structure-based design of platinum(II) Complexes as c-myc oncogene Down-regulators and luminescent probes for G-quadruplex DNA
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| Publication |
Silver(i)-mediated highly enantioselective synthesis of axially chiral allenes under thermal and microwave-assisted conditions
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| Publication |
Analysis of melamine cyanurate in urine using matrix-assisted laser desorption/ionization mass spectrometry
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