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Grant:
A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
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Project Title
A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Principal Investigator
Xu, Aimin (Principal investigator)
Co-Investigator(s)
Lam, Karen Siu Ling (Co-Investigator)
Vanhoutte, Paul Michel Georges Remi (Co-Investigator)
Wang, Yu (Co-Investigator)
Professor Huang Yu (Co-Investigator)
Project Code
HKU4/CRF/10
Funding Year
2010/2011
Amount
6330000
Panel
Medicine
Start Date
25-06-2011
Expected Completion
24-06-2014
Status
On-going
Keywords
Diabetes, Obesity, Vascular inflammation, endothelial dysfunction, Cardiovascular disease
Discipline
Cardiovascular Research, Diabetes/Metabolism
Sponsor
RGC Collaborative Research Fund (CRF)
Grant Type/Funding Scheme
Collaborative Research Fund (CRF) - Group Research Project
Duration
36
Publication
Small lipid-binding proteins in regulating endothelial and vascular functions: Focusing on adipocyte fatty acid binding protein and lipocalin-2
Publication
APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice
Publication
Adiponectin and cardiovascular health: An update
Publication
APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice
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