Grant: Characterization of highly active, thermostable mutants of Trigonopsis variabilis D-Amino acid oxidase for antibiotics production: Kinetic measurements, structural studies and beyond
| Project Title |
Characterization of highly active, thermostable mutants of Trigonopsis variabilis D-Amino acid oxidase for antibiotics production: Kinetic measurements, structural studies and beyond
|
|---|---|
| Principal Investigator | Tsang, Wai Kei (Principal investigator) |
| Co-Investigator(s) |
Professor Fong Wing Ping
(Co-Investigator)
|
| Project Code |
HKU 475007M
|
| Funding Year |
2007/2008
|
| Amount |
404946
|
| Panel | Biology and Medicine (M) |
| Start Date |
01-01-2008
|
| Expected Completion |
30-06-2010
|
| Status |
Completed
|
| Keywords | D-Amino acid oxidase, Crystallography, T.variabilis, Subsitution |
| Discipline | Biochemistry, Others - Biological Sciences |
| Sponsor | RGC General Research Fund (GRF) |
| Grant Type/Funding Scheme | General Research Fund (GRF) |
| Duration |
30
|
| Publication | A single Phe54Tyr substitution improves the catalytic activity and thermostability of Trigonopsis variabilis d-amino acid oxidase |
| Publication | Entrapment of a Trigonopsis variabilis D-amino acid oxidase variant F54Y for oxidative deamination of cephalosporin C |
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