| Project Title |
Control of Pandemic and Inter-pandemic Influenza
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| Principal Investigator |
Peiris, Joseph Sriyal Malik
(Principal investigator)
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| Co-Investigator(s) |
Lau, Yu Lung
(Co-Investigator)
Yuen, Kwok Yung
(Co-Investigator)
Chen, Honglin
(Co-Investigator)
Guan, Yi
(Co-Investigator)
Leung, Gabriel Matthew
(Co-Investigator)
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| Project Code |
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| Funding Year |
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| Amount |
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| Start Date |
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| Expected Completion |
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| Status |
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| Keywords |
influenza
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| Sponsor |
RGC Areas of Excellence (AoE)
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| Grant Type/Funding Scheme |
Areas of Excellence Scheme
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| Duration |
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| Publication |
Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells
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| Publication |
Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation
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| Publication |
The development and genetic diversity of H5N1 influenza virus in China, 1996-2006
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| Publication |
Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM + memory B cells
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| Publication |
Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein
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| Publication |
Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza a epidemic
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| Publication |
Molecular detection of a novel human influenza (H1N1) of pandemic potential by conventional and real-time quantitative RT-PCR assays
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| Publication |
A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase
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| Publication |
Immunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: A randomized controlled trial
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| Publication |
Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice
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| Publication |
Design of multiplexed detection assays for identification of avian influenza a virus subtypes pathogenic to humans by SmartCycler real-time reverse transcription-PCR
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| Publication |
Effects of school closures, 2008 winter influenza season, Hong Kong
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| Publication |
Influenza virus in human exhaled breath: An observational study
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| Publication |
Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses
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| Publication |
Estimation of the serial interval of influenza
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| Publication |
Identification of influenza A nucleoprotein as an antiviral target
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| Publication |
Dating the emergence of pandemic influenza viruses
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| Publication |
Analytical sensitivity of rapid influenza antigen detection tests for swine-origin influenza virus (H1N1)
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| Publication |
Phosphoantigen-expanded human γδ T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses
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| Publication |
Comparison of the NucliSens easyMAG and Qiagen BioRobot 9604 nucleic acid extraction systems for detection of RNA and DNA respiratory viruses in nasopharyngeal aspirate samples
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| Publication |
Viral genetic determinants of h5n1 influenza viruses that contribute to cytokine dysregulation
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| Publication |
DAS181 inhibits H5N1 influenza virus infection of human lung tissues
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| Publication |
Virologically confirmed population-based burden of hospitalization caused by influenza a and b among children in Hong Kong
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| Publication |
Influenza virus directly infects human natural killer cells and induces cell apoptosis
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| Publication |
One step closer to universal influenza epitopes
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| Publication |
Entry screening to delay local transmission of 2009 pandemic influenza A (H1N1)
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| Publication |
Face masks to prevent transmission of influenza virus: a systematic review
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| Publication |
Seasonal effects of influenza on mortality in a subtropical city
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| Publication |
School closure and mitigation of pandemic (H1N1) 2009, Hong Kong
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| Publication |
Viral shedding and clinical illness in naturally acquired influenza virus infections
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| Publication |
A profile of the online dissemination of national influenza surveillance data
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| Publication |
Effects of oseltamivir treatment on duration of clinical illness and viral shedding and household transmission of influenza virus
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| Publication |
Preliminary findings of a randomized trial of non-pharmaceutical interventions to prevent influenza transmission in households
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| Publication |
Prevalence of antibodies against avian influenza A (H5N1) virus among cullers and poultry workers in Ho Chi Minh City, 2005
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| Publication |
Quasispecies of the D225G substitution in the hemagglutinin of pandemic influenza A(H1N1) 2009 virus from patients with severe disease in Hong Kong, China
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| Publication |
Factors affecting QuickVue Influenza A + B rapid test performance in the community setting
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| Publication |
Comparative epidemiology of pandemic and seasonal influenza A in households
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| Publication |
Evaluation of novel H1N1-specific primer-probe sets using commercial RT-PCR mixtures and a premixed reaction stored in a lyophilized format
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| Publication |
Mutations in influenza virus replication and transcription: Detection of amino acid substitutions in hemagglutinin of an avian influenza virus (H1N1)
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| Publication |
An M2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses
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| Publication |
Identification of unusual truncated forms of nucleocapsid protein in MDCK cells infected by Avian influenza virus (H9N2).
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| Publication |
Establishment of an H6N2 influenza virus lineage in domestic ducks in southern China
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| Publication |
2009 Pandemic H1N1 Influenza virus replicates in human lung tissues
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| Publication |
A novel H1N1 virus causes the first pandemic of the 21st century
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| Publication |
Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
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| Publication |
Inhibition of human natural killer cell activity by influenza virions and hemagglutinin
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| Publication |
Natural killer cells become tolerogenic after interaction with apoptotic cells
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| Publication |
Rapid detection of reassortment of pandemic H1N1/2009 influenza virus
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| Publication |
Cellular response to influenza virus infection: A potential role for autophagy in CXCL10 and interferon-alpha induction
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| Publication |
Influenza a virus expresses high levels of an unusual class of small viral leader RNAs in infected cells
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| Publication |
Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong
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| Publication |
Community psychological and behavioral responses through the first wave of the 2009 influenza A(H1N1) pandemic in Hong Kong
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| Publication |
Logistical feasibility and potential benefits of a population-wide passive-immunotherapy program during an influenza pandemic
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| Publication |
Situational awareness and health protective responses to pandemic influenza A (H1N1) in Hong Kong: A cross-sectional study
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| Publication |
The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong
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| Publication |
The effective reproduction number of pandemic influenza: Prospective estimation
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| Publication |
Kinetics of neutralizing antibodies in patients naturally infected by H5N1 virus.
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| Publication |
Optimization and evaluation of an influenza A (H5) pseudotyped lentiviral particle-based serological assay
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| Publication |
The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis
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| Publication |
Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses
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| Publication |
Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus
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| Publication |
DNA intercalator stimulates influenza transcription and virus replication
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| Publication |
Long-term evolution and transmission dynamics of swine influenza A virus
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| Publication |
A highly conserved neutralizing epitope on group 2 influenza A viruses
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| Publication |
Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant
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| Publication |
Age-Matched comparison of children hospitalized for 2009 pandemic H1N1 influenza with those hospitalized for seasonal H1N1 and H3N2
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| Publication |
Epidemiological characteristics of 2009 (H1N1) pandemic influenza based on paired sera from a longitudinal community cohort study
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| Publication |
Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong
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| Publication |
Factors affecting intention to receive and self-reported receipt of 2009 pandemic (H1N1) vaccine in Hong Kong: A longitudinal study
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| Publication |
Type 1 responses of human Vγ9Vδ2 T cells to influenza A viruses
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| Publication |
Generation of human Th1-like regulatory CD4 + T cells by an intrinsic IFN-γ- and T-bet-dependent pathway
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| Publication |
Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract
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| Publication |
The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice
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| Publication |
Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function
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| Publication |
Circulating influenza virus, climatic factors, and acute myocardial infarction: A time series study in England and Wales and Hong Kong
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| Publication |
The use of mathematical models to inform influenza pandemic preparedness and response
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| Publication |
Production of influenza pseudotyped lentiviral particles and their use influenza research and diagnosis: an update
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| Publication |
Reassortment of pandemic H1N1/2009 influenza a virus in swine
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| Publication |
Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro
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| Publication |
Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro
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| Publication |
Avian influenza H5N1 virus induces cytopathy and proinflammatory cytokine responses in human astrocytic and neuronal cell lines
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| Publication |
Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages.
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| Publication |
Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice
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| Publication |
Host response to influenza virus: Protection versus immunopathology
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| Publication |
Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets
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| Publication |
Reassortment events among swine influenza a viruses in China: Implications for the origin of the 2009 influenza pandemic
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| Publication |
Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China
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| Publication |
Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination
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| Publication |
Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses
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| Publication |
Estimating infection attack rates and severity in real time during an influenza pandemic: Analysis of serial cross-sectional serologic surveillance data
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| Publication |
Transmissibility of seasonal and pandemic influenza in a cohort of households in Hong Kong in 2009
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| Publication |
Seroprevalence of pandemic h1n1 antibody among health care workers in hong kong following receipt of monovalent 2009 h1n1 influenza vaccine
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| Publication |
Influenza associated mortality in the subtropics and tropics: Results from three Asian cities
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| Publication |
Estimating incidence curves of several infections using symptom surveillance data
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| Publication |
An analysis of national target groups for monovalent 2009 pandemic influenza vaccine and trivalent seasonal influenza vaccines in 2009-10 and 2010-11
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| Publication |
Optimal design of studies of influenza transmission in households. I: Case-ascertained studies
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| Publication |
Digital dashboard design using multiple data streams for disease surveillance with influenza surveillance as an example
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| Publication |
Validation of self-swab for virologic confirmation of influenza virus infections in a community setting
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| Publication |
Effect modification of environmental factors on influenza-associated mortality: a time-series study in two Chinese cities
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| Publication |
Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection
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| Publication |
DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis.
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| Publication |
Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis
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| Publication |
Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva
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| Publication |
Detection of highly pathogenic influenza and pandemic influenza virus in formalin fixed tissues by immunohistochemical methods
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| Publication |
Optimal design of intervention studies to prevent influenza in healthy cohorts
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| Publication |
Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia
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| Publication |
Innate immune responses to influenza A H5N1: friend or foe?
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| Publication |
A secondary sialic acid binding site on influenza virus neuraminidase: fact or fiction?
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| Publication |
Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine
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| Publication |
Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community
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| Publication |
Seroconversion to pandemic (H1N1) 2009 virus and cross-reactive immunity to other swine influenza viruses
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| Publication |
The feasibility of age-specific travel restrictions during influenza pandemics
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| Publication |
Situational awareness of influenza activity based on multiple streams of surveillance data using multivariate dynamic linear model
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| Publication |
Phenotypic and functional characterization of human γδT-cell subsets in response to influenza a viruses
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| Publication |
Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesis
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| Publication |
Gene flow and competitive exclusion of avian influenza A virus in natural reservoir hosts
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| Publication |
Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: Infectious potential for humans
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