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Article: Liquid-Based Cytology and Conventional Cervical Smears: A Comparison Study in an Asian Screening Population

TitleLiquid-Based Cytology and Conventional Cervical Smears: A Comparison Study in an Asian Screening Population
Authors
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2003, v. 99 n. 6, p. 331-335 How to Cite?
AbstractBACKGROUND. This study compared the findings of cervical cytology screening by ThinPrep Papanicoloau (Pap) tests (TP) with the findings of screening by conventional cervical smears (CS) in a screening population involving what to the authors' knowledge is the largest sample of ThinPrep Pap tests published to date. METHOD. Data from 191,581 CS that were screened in the period from March 1, 1998 to February 28, 2000 were compared with data from 190,667 TP performed from March 1, 2000 to February 28, 2002 and that were obtained from the same sources. RESULTS. With TP, the unsatisfactory rate was reduced from 0.48% to 0.32%. Fewer cases were considered to be suboptimal (19.12% vs. 12.97%). The detection rates of squamous cell carinomas, adenocarcinomas, and high-grade squamous intraepithelial lesions (HSIL) were essentially unchanged in the TP group (0.005%, 0.003%, and 0.25%, respectively) compared with the rates for the CS group (0.01%, 0.006%, and 0.25%, respectively). There was an increase in the detection of atypical squamous cells of undetermined significance (ASCUS; 3.74% vs. 3.19%) and low-grade SIL (LSIL; 1.67% vs. 1.01%) with a decrease in the ASCUS-to-LSIL ratio from 3.15 for CS to 2.33 for TP. The detection of atypical glandular cells of undetermined significance (AGUS) increased slightly from 0.07% to 0.09%. The proportion of cells reported to have reactive atypia dropped from 2.71% to 1.48%. Limited biopsy correlation (range, 73.2-76.2%) confirmed the increased sensitivity of TP. More actinomyces (1.07% vs. 0.52%) were detected in TP samples despite of a similar portion of intrauterine-device users. The average primary screening and rapid rescreening time of each slide were reduced from 8 minutes to 4 minutes and from 2 minutes to less than 1 minute, respectively. CONCLUSIONS. The preliminary experience of the authors of the current studys appears to support the use of the ThinPrep Pap test to enhance the efficiency of cervical cytology screening. © 2003 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/88521
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorSzeto, EFen_HK
dc.contributor.authorLeung, BSYen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorNg, AWYen_HK
dc.date.accessioned2010-09-06T09:44:27Z-
dc.date.available2010-09-06T09:44:27Z-
dc.date.issued2003en_HK
dc.identifier.citationCancer, 2003, v. 99 n. 6, p. 331-335en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/88521-
dc.description.abstractBACKGROUND. This study compared the findings of cervical cytology screening by ThinPrep Papanicoloau (Pap) tests (TP) with the findings of screening by conventional cervical smears (CS) in a screening population involving what to the authors' knowledge is the largest sample of ThinPrep Pap tests published to date. METHOD. Data from 191,581 CS that were screened in the period from March 1, 1998 to February 28, 2000 were compared with data from 190,667 TP performed from March 1, 2000 to February 28, 2002 and that were obtained from the same sources. RESULTS. With TP, the unsatisfactory rate was reduced from 0.48% to 0.32%. Fewer cases were considered to be suboptimal (19.12% vs. 12.97%). The detection rates of squamous cell carinomas, adenocarcinomas, and high-grade squamous intraepithelial lesions (HSIL) were essentially unchanged in the TP group (0.005%, 0.003%, and 0.25%, respectively) compared with the rates for the CS group (0.01%, 0.006%, and 0.25%, respectively). There was an increase in the detection of atypical squamous cells of undetermined significance (ASCUS; 3.74% vs. 3.19%) and low-grade SIL (LSIL; 1.67% vs. 1.01%) with a decrease in the ASCUS-to-LSIL ratio from 3.15 for CS to 2.33 for TP. The detection of atypical glandular cells of undetermined significance (AGUS) increased slightly from 0.07% to 0.09%. The proportion of cells reported to have reactive atypia dropped from 2.71% to 1.48%. Limited biopsy correlation (range, 73.2-76.2%) confirmed the increased sensitivity of TP. More actinomyces (1.07% vs. 0.52%) were detected in TP samples despite of a similar portion of intrauterine-device users. The average primary screening and rapid rescreening time of each slide were reduced from 8 minutes to 4 minutes and from 2 minutes to less than 1 minute, respectively. CONCLUSIONS. The preliminary experience of the authors of the current studys appears to support the use of the ThinPrep Pap test to enhance the efficiency of cervical cytology screening. © 2003 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdenocarcinoma - diagnosis - pathologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAsiaen_HK
dc.subject.meshCarcinoma, Squamous Cell - diagnosis - pathologyen_HK
dc.subject.meshCervical Intraepithelial Neoplasia - diagnosis - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMass Screeningen_HK
dc.subject.meshMicrotomyen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshSpecimen Handlingen_HK
dc.subject.meshUterine Cervical Neoplasms - diagnosis - pathologyen_HK
dc.subject.meshVaginal Smears - methodsen_HK
dc.titleLiquid-Based Cytology and Conventional Cervical Smears: A Comparison Study in an Asian Screening Populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=99&issue=6&spage=331&epage=335&date=2003&atitle=Liquid-based+cytology+and+conventional+cervical+smears:+a+comparison+study+in+an+Asian+screening+populationen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cncr.11786en_HK
dc.identifier.pmid14681939-
dc.identifier.scopuseid_2-s2.0-0347512093en_HK
dc.identifier.hkuros86086en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347512093&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue6en_HK
dc.identifier.spage331en_HK
dc.identifier.epage335en_HK
dc.identifier.isiWOS:000187404200002-
dc.publisher.placeUnited Statesen_HK

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