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Article: A prospective randomized study to compare the use of repeated doses of vaginal with sublingual misoprostol in the management of first trimester silent miscarriages

TitleA prospective randomized study to compare the use of repeated doses of vaginal with sublingual misoprostol in the management of first trimester silent miscarriages
Authors
KeywordsFirst trimester
Miscarriages
Misoprostol
Sublingual
Vaginal
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2003, v. 18 n. 1, p. 176-181 How to Cite?
AbstractBackground: A randomized controlled trial comparing sublingual with vaginal administration of misoprostol for medical management of silent miscarriages. Methods: Eighty women who had silent miscarriages (<13 weeks) were randomized to receive 600 μg of misoprostol every 3 h for a maximum of three doses either sublingually or vaginally. Results: The success rates of medical management were the same in both groups (87.5%; 95% CI: 74-95%). There were no serious complications. The incidence of diarrhoea was higher in the sublingual (70%) than the vaginal route (27.5%) (P < 0.005). Other side effects were similar in each group, although fatigue was experienced by more women in the sublingual group than in the vaginal group (65 versus 40%: P = 0.043). The overall acceptability of medical management was good. Most women would choose the medical method if they were allowed to choose again and would recommend the method to others. Conclusion: The current regimen of misoprostol is useful for the management of silent miscarriage in terms of complete miscarriage rate and patient acceptability. Sublingual misoprostol may offer an alternative for women who do not like repeated vaginal administration of the drug.
Persistent Identifierhttp://hdl.handle.net/10722/87144
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, OSen_HK
dc.contributor.authorLau, WNTen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorLee, SWHen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:25:53Z-
dc.date.available2010-09-06T09:25:53Z-
dc.date.issued2003en_HK
dc.identifier.citationHuman Reproduction, 2003, v. 18 n. 1, p. 176-181en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87144-
dc.description.abstractBackground: A randomized controlled trial comparing sublingual with vaginal administration of misoprostol for medical management of silent miscarriages. Methods: Eighty women who had silent miscarriages (<13 weeks) were randomized to receive 600 μg of misoprostol every 3 h for a maximum of three doses either sublingually or vaginally. Results: The success rates of medical management were the same in both groups (87.5%; 95% CI: 74-95%). There were no serious complications. The incidence of diarrhoea was higher in the sublingual (70%) than the vaginal route (27.5%) (P < 0.005). Other side effects were similar in each group, although fatigue was experienced by more women in the sublingual group than in the vaginal group (65 versus 40%: P = 0.043). The overall acceptability of medical management was good. Most women would choose the medical method if they were allowed to choose again and would recommend the method to others. Conclusion: The current regimen of misoprostol is useful for the management of silent miscarriage in terms of complete miscarriage rate and patient acceptability. Sublingual misoprostol may offer an alternative for women who do not like repeated vaginal administration of the drug.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectFirst trimesteren_HK
dc.subjectMiscarriagesen_HK
dc.subjectMisoprostolen_HK
dc.subjectSublingualen_HK
dc.subjectVaginalen_HK
dc.titleA prospective randomized study to compare the use of repeated doses of vaginal with sublingual misoprostol in the management of first trimester silent miscarriagesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=18&issue=1&spage=176&epage=181&date=2003&atitle=A+prospective+randomized+study+to+compare+the+use+of+repeated+doses+of+vaginal+with+sublingual+misoprostol+in+the+management+of+first+trimester+silent+miscarriagesen_HK
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/humrep/deg013en_HK
dc.identifier.pmid12525463-
dc.identifier.scopuseid_2-s2.0-0037248046en_HK
dc.identifier.hkuros76881en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037248046&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue1en_HK
dc.identifier.spage176en_HK
dc.identifier.epage181en_HK
dc.identifier.isiWOS:000180570300033-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTang, OS=7006723402en_HK
dc.identifier.scopusauthoridLau, WNT=36847553600en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridLee, SWH=26030998000en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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