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Article: Plasma lipid, lipoprotein and apolipoprotein levels in a random population sample of 2875 Hong Kong Chinese adults and their implications (NCEP ATP-III, 2001 guidelines) on cardiovascular risk assessment

TitlePlasma lipid, lipoprotein and apolipoprotein levels in a random population sample of 2875 Hong Kong Chinese adults and their implications (NCEP ATP-III, 2001 guidelines) on cardiovascular risk assessment
Authors
KeywordsApolipoprotein E
Cardiovascular risk factors
Chinese
Epidemiology
Hong Kong
Lipid profiles
Lipoprotein(a)
Postmenopausal
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 2006, v. 184 n. 2, p. 438-445 How to Cite?
AbstractThe age- and sex-related levels of plasma lipids, lipoproteins and apolipoproteins in a random population sample of 2875 Hong Kong Chinese Adults (1397 men and 1478 women aged 25-74) and their implications on cardiovascular risk assessment are reported. Total cholesterol, low-density lipoprotein (LDL)-cholesterol and triglycerides increased with age in both sexes. Postmenopausal women had the worst profiles. They also showed higher triglyceride and non-high density lipoprotein (non-HDL)-cholesterol and had higher percentage of values greater than the desirable limits, compared with men of the same age groups. Overall 39% of men and 29% of women had non-HDL cholesterol of 4.2 mmol/L or greater. Apolipoproteins A-I and B followed the same trends as HDL-cholesterol and LDL-cholesterol, respectively. Apolipoprotein E (apo E) allele frequencies were: ε2 8.7, ε3 80.4 and ε4 10.9% with the genotype having a significant effect on plasma apo E concentration (p < 0.001). Carriers of the ε2 allele had higher apo E values than those homozygous for E3. Lipoprotein(a) levels were higher in women than men (geometric mean 152 versus 102 mg/L, p < 0.05) and in women with FSH above versus below 40 IU/L (185 versus 136 mg/L, p < 0.05). With respect to the NCEP ATP-III 2001 guidelines, the prevalence of hyperlipidemia in the Hong Kong population approached those in high CHD prevalence Caucasian communities. Local management guidelines and community-wide programs to reduce fat intake, increase regular moderate exercise and reduce the prevalence of overweight and obesity are urgently required, and hormone replacement therapy for postmenopausal women might be warranted. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/86923
ISSN
2015 Impact Factor: 3.942
2015 SCImago Journal Rankings: 1.819
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPang, RWCen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorSiu, STSen_HK
dc.contributor.authorMa, OCKen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T09:22:59Z-
dc.date.available2010-09-06T09:22:59Z-
dc.date.issued2006en_HK
dc.identifier.citationAtherosclerosis, 2006, v. 184 n. 2, p. 438-445en_HK
dc.identifier.issn0021-9150en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86923-
dc.description.abstractThe age- and sex-related levels of plasma lipids, lipoproteins and apolipoproteins in a random population sample of 2875 Hong Kong Chinese Adults (1397 men and 1478 women aged 25-74) and their implications on cardiovascular risk assessment are reported. Total cholesterol, low-density lipoprotein (LDL)-cholesterol and triglycerides increased with age in both sexes. Postmenopausal women had the worst profiles. They also showed higher triglyceride and non-high density lipoprotein (non-HDL)-cholesterol and had higher percentage of values greater than the desirable limits, compared with men of the same age groups. Overall 39% of men and 29% of women had non-HDL cholesterol of 4.2 mmol/L or greater. Apolipoproteins A-I and B followed the same trends as HDL-cholesterol and LDL-cholesterol, respectively. Apolipoprotein E (apo E) allele frequencies were: ε2 8.7, ε3 80.4 and ε4 10.9% with the genotype having a significant effect on plasma apo E concentration (p < 0.001). Carriers of the ε2 allele had higher apo E values than those homozygous for E3. Lipoprotein(a) levels were higher in women than men (geometric mean 152 versus 102 mg/L, p < 0.05) and in women with FSH above versus below 40 IU/L (185 versus 136 mg/L, p < 0.05). With respect to the NCEP ATP-III 2001 guidelines, the prevalence of hyperlipidemia in the Hong Kong population approached those in high CHD prevalence Caucasian communities. Local management guidelines and community-wide programs to reduce fat intake, increase regular moderate exercise and reduce the prevalence of overweight and obesity are urgently required, and hormone replacement therapy for postmenopausal women might be warranted. © 2005 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosisen_HK
dc.relation.ispartofAtherosclerosisen_HK
dc.rightsAtherosclerosis. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectApolipoprotein Een_HK
dc.subjectCardiovascular risk factorsen_HK
dc.subjectChineseen_HK
dc.subjectEpidemiologyen_HK
dc.subjectHong Kongen_HK
dc.subjectLipid profilesen_HK
dc.subjectLipoprotein(a)en_HK
dc.subjectPostmenopausalen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshApolipoproteins - blooden_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshBiological Markers - blooden_HK
dc.subject.meshCardiovascular Diseases - blood - ethnologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshLipoproteins - blooden_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPopulation Surveillanceen_HK
dc.subject.meshPractice Guidelines as Topicen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRisk Assessmenten_HK
dc.subject.meshSex Distributionen_HK
dc.titlePlasma lipid, lipoprotein and apolipoprotein levels in a random population sample of 2875 Hong Kong Chinese adults and their implications (NCEP ATP-III, 2001 guidelines) on cardiovascular risk assessmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9150&volume=184&spage=438&epage=445&date=2006&atitle=Plasma+lipid,+lipoprotein+and+apolipoprotein+levels+in+a+random+population+sample+of+2875+Hong+Kong+Chinese+adults+and+their+implications+(NCEP+ATP-III,+2001+guidelines)+on+cardiovascular+risk+assessmenten_HK
dc.identifier.emailPang, RWC: robertap@hkucc.hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityPang, RWC=rp00274en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.atherosclerosis.2005.05.013en_HK
dc.identifier.pmid16475254en_HK
dc.identifier.scopuseid_2-s2.0-30044443185en_HK
dc.identifier.hkuros115461en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-30044443185&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume184en_HK
dc.identifier.issue2en_HK
dc.identifier.spage438en_HK
dc.identifier.epage445en_HK
dc.identifier.isiWOS:000235317500027-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridPang, RWC=7004376659en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridSiu, STS=7006115274en_HK
dc.identifier.scopusauthoridMa, OCK=7004452841en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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