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Article: Characterization of a human H5N1 influenza a virus isolated in 2003

TitleCharacterization of a human H5N1 influenza a virus isolated in 2003
Authors
Issue Date2005
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2005, v. 79 n. 15, p. 9926-9932 How to Cite?
AbstractIn 2003, H5N1 avian influenza virus infections were diagnosed in two Hong Kong residents who had visited the Fujian province in mainland China, affording us the opportunity to characterize one of the viral isolates, A/Hong Kong/213/03 (HK213; H5N1). In contrast to H5N1 viruses isolated from humans during the 1997 outbreak in Hong Kong, HK213 retained several features of aquatic bird viruses, including the lack of a deletion in the neuraminidase stalk and the absence of additional oligosaccharide chains at the globular head of the hemagglutinin molecule. It demonstrated weak pathogenicity in mice and ferrets but caused lethal infection in chickens. The original isolate failed to produce disease in ducks but became more pathogenic after five passages. Taken together, these findings portray the HK213 isolate as an aquatic avian influenza A virus without the molecular changes associated with the replication of H5N1 avian viruses in land-based poultry such as chickens. This case challenges the view that adaptation to land-based poultry is a prerequisite for the replication of aquatic avian influenza A viruses in humans. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79161
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShinya, Ken_HK
dc.contributor.authorHatta, Men_HK
dc.contributor.authorYamada, Sen_HK
dc.contributor.authorTakada, Aen_HK
dc.contributor.authorWatanabe, Sen_HK
dc.contributor.authorHalfmann, Pen_HK
dc.contributor.authorHorimoto, Ten_HK
dc.contributor.authorNeumann, Gen_HK
dc.contributor.authorKim, JHen_HK
dc.contributor.authorLim, Wen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorKiso, Men_HK
dc.contributor.authorSuzuki, Ten_HK
dc.contributor.authorSuzuki, Yen_HK
dc.contributor.authorKawaoka, Yen_HK
dc.date.accessioned2010-09-06T07:51:20Z-
dc.date.available2010-09-06T07:51:20Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Virology, 2005, v. 79 n. 15, p. 9926-9932en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/79161-
dc.description.abstractIn 2003, H5N1 avian influenza virus infections were diagnosed in two Hong Kong residents who had visited the Fujian province in mainland China, affording us the opportunity to characterize one of the viral isolates, A/Hong Kong/213/03 (HK213; H5N1). In contrast to H5N1 viruses isolated from humans during the 1997 outbreak in Hong Kong, HK213 retained several features of aquatic bird viruses, including the lack of a deletion in the neuraminidase stalk and the absence of additional oligosaccharide chains at the globular head of the hemagglutinin molecule. It demonstrated weak pathogenicity in mice and ferrets but caused lethal infection in chickens. The original isolate failed to produce disease in ducks but became more pathogenic after five passages. Taken together, these findings portray the HK213 isolate as an aquatic avian influenza A virus without the molecular changes associated with the replication of H5N1 avian viruses in land-based poultry such as chickens. This case challenges the view that adaptation to land-based poultry is a prerequisite for the replication of aquatic avian influenza A viruses in humans. Copyright © 2005, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtype-
dc.subject.meshInfluenza A virus - pathogenicity - physiology-
dc.subject.meshInfluenza, Human - epidemiology - veterinary - virology-
dc.subject.meshPoultry Diseases - virology-
dc.subject.meshReceptors, Virus - metabolism-
dc.titleCharacterization of a human H5N1 influenza a virus isolated in 2003en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=79&issue=15&spage=9926&epage=32&date=2005&atitle=Characterization+of+a+human H5N1+influenza+A+virus+isolated+in+2003.en_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.79.15.9926-9932.2005en_HK
dc.identifier.pmid16014953-
dc.identifier.pmcidPMC1181571-
dc.identifier.scopuseid_2-s2.0-22544445276en_HK
dc.identifier.hkuros110184en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-22544445276&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume79en_HK
dc.identifier.issue15en_HK
dc.identifier.spage9926en_HK
dc.identifier.epage9932en_HK
dc.identifier.isiWOS:000230575300054-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShinya, K=7004441613en_HK
dc.identifier.scopusauthoridHatta, M=7004521317en_HK
dc.identifier.scopusauthoridYamada, S=35418940500en_HK
dc.identifier.scopusauthoridTakada, A=7202962935en_HK
dc.identifier.scopusauthoridWatanabe, S=35371645500en_HK
dc.identifier.scopusauthoridHalfmann, P=6507195617en_HK
dc.identifier.scopusauthoridHorimoto, T=7004547083en_HK
dc.identifier.scopusauthoridNeumann, G=7202631658en_HK
dc.identifier.scopusauthoridKim, JH=26664082200en_HK
dc.identifier.scopusauthoridLim, W=7202378277en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridKiso, M=36068114400en_HK
dc.identifier.scopusauthoridSuzuki, T=7409095746en_HK
dc.identifier.scopusauthoridSuzuki, Y=7407199530en_HK
dc.identifier.scopusauthoridKawaoka, Y=26643027000en_HK

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