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Article: Cyclooxygenase-2 inhibition and gastric cancer

TitleCyclooxygenase-2 inhibition and gastric cancer
Authors
Issue Date2003
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cpd/index.htm
Citation
Current Pharmaceutical Design, 2003, v. 9 n. 27, p. 2281-2288 How to Cite?
AbstractEpidemiological evidences suggest that chronic use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) might be associated with a reduced risk of gastrointestinal cancers, including gastric cancer. The pre-cancerous gastric lesions and gastric cancers over-expressed cyclooxygenase (COX)-2. This overexpression not only is associated with Helicobacter pylori infection, but also maybe due to exposure to carcinogens. Targeted inhibition of COX, especially the COX-2 isoform, can lead to growth inhibition and apoptosis of gastric cancer in vitro. Various mechanisms, including COX-dependent and COX-independent pathways, have been identified and will be discussed in this article. Animal xenograft models have confirmed the tumor suppressing effects of COX-2 inhibitors. Human studies are underway to examine the use of COX-2 inhibitor in the treatment of pre-cancerous lesions. COX-2 inhibitors have a promising role in the prevention and treatment of gastric cancer.
Persistent Identifierhttp://hdl.handle.net/10722/78522
ISSN
2015 Impact Factor: 3.052
2015 SCImago Journal Rankings: 1.220
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJiang, XHen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:43:49Z-
dc.date.available2010-09-06T07:43:49Z-
dc.date.issued2003en_HK
dc.identifier.citationCurrent Pharmaceutical Design, 2003, v. 9 n. 27, p. 2281-2288en_HK
dc.identifier.issn1381-6128en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78522-
dc.description.abstractEpidemiological evidences suggest that chronic use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) might be associated with a reduced risk of gastrointestinal cancers, including gastric cancer. The pre-cancerous gastric lesions and gastric cancers over-expressed cyclooxygenase (COX)-2. This overexpression not only is associated with Helicobacter pylori infection, but also maybe due to exposure to carcinogens. Targeted inhibition of COX, especially the COX-2 isoform, can lead to growth inhibition and apoptosis of gastric cancer in vitro. Various mechanisms, including COX-dependent and COX-independent pathways, have been identified and will be discussed in this article. Animal xenograft models have confirmed the tumor suppressing effects of COX-2 inhibitors. Human studies are underway to examine the use of COX-2 inhibitor in the treatment of pre-cancerous lesions. COX-2 inhibitors have a promising role in the prevention and treatment of gastric cancer.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cpd/index.htmen_HK
dc.relation.ispartofCurrent Pharmaceutical Designen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshClinical Trials as Topic - statistics & numerical dataen_HK
dc.subject.meshCyclooxygenase 2en_HK
dc.subject.meshCyclooxygenase 2 Inhibitorsen_HK
dc.subject.meshCyclooxygenase Inhibitors - pharmacology - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIsoenzymes - antagonists & inhibitors - metabolismen_HK
dc.subject.meshMembrane Proteinsen_HK
dc.subject.meshProstaglandin-Endoperoxide Synthases - metabolismen_HK
dc.subject.meshStomach Neoplasms - drug therapy - enzymologyen_HK
dc.titleCyclooxygenase-2 inhibition and gastric canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1381-6128&volume=9&issue=27&spage=2281&epage=8&date=2003&atitle=Cyclooxygenase-2+Inhibition+and+Gastric+Canceren_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/1381612033453983en_HK
dc.identifier.pmid14529406-
dc.identifier.scopuseid_2-s2.0-0141449984en_HK
dc.identifier.hkuros86756en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141449984&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue27en_HK
dc.identifier.spage2281en_HK
dc.identifier.epage2288en_HK
dc.identifier.isiWOS:000185300600011-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridJiang, XH=36089034900en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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