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Article: A pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levels

TitleA pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levels
Authors
KeywordsAplastic anemia
Hemosiderosis
Myelodysplasia
Issue Date2008
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182
Citation
Hematological Oncology, 2008, v. 26 n. 4, p. 225-228 How to Cite?
AbstractWe performed MRI and endocrine assessment in 27 adult Chinese patients with severe aplastic anemia (SAA) and myelodysplasia (MDS). Despite high ferritin levels, cardiac hemosiderosis and heart failure was not common, and were not concordant in most cases. However, significant correlation was found between cardiac T2/T2* MRI assessment, ejection fraction and ferritin levels. Furthermore, there was a high incidence subclinical pancreatic abnormality that was related to liver MRI T2* readings. Hence, chelating agents may still have a role to improve organ function. Prospective data with serial functional and imaging monitoring is needed. Copyright © 2008 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/77638
ISSN
2015 Impact Factor: 3.494
2015 SCImago Journal Rankings: 0.767
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, Wen_HK
dc.contributor.authorLam, WWMen_HK
dc.contributor.authorChu, WWCen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorWong, WKen_HK
dc.contributor.authorChan, Hen_HK
dc.contributor.authorLaw, MFen_HK
dc.contributor.authorLiu, HSYen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-09-06T07:34:05Z-
dc.date.available2010-09-06T07:34:05Z-
dc.date.issued2008en_HK
dc.identifier.citationHematological Oncology, 2008, v. 26 n. 4, p. 225-228en_HK
dc.identifier.issn0278-0232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77638-
dc.description.abstractWe performed MRI and endocrine assessment in 27 adult Chinese patients with severe aplastic anemia (SAA) and myelodysplasia (MDS). Despite high ferritin levels, cardiac hemosiderosis and heart failure was not common, and were not concordant in most cases. However, significant correlation was found between cardiac T2/T2* MRI assessment, ejection fraction and ferritin levels. Furthermore, there was a high incidence subclinical pancreatic abnormality that was related to liver MRI T2* readings. Hence, chelating agents may still have a role to improve organ function. Prospective data with serial functional and imaging monitoring is needed. Copyright © 2008 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182en_HK
dc.relation.ispartofHematological Oncologyen_HK
dc.rightsHematological Oncology. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectAplastic anemiaen_HK
dc.subjectHemosiderosisen_HK
dc.subjectMyelodysplasiaen_HK
dc.titleA pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levelsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-0232&volume=&spage=&epage=&date=2008&atitle=A+pilot+MRI+study+of+organ+specific+hemosiderosis+and+functional+correlation+in+Chinese+patients+with+myelodysplasia+and+aplastic+anemia+with+raised+ferritin+levelsen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hon.862en_HK
dc.identifier.scopuseid_2-s2.0-58949095477en_HK
dc.identifier.hkuros146156en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58949095477&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue4en_HK
dc.identifier.spage225en_HK
dc.identifier.epage228en_HK
dc.identifier.isiWOS:000262068900005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, W=7202383089en_HK
dc.identifier.scopusauthoridLam, WWM=26024322600en_HK
dc.identifier.scopusauthoridChu, WWC=26532214400en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridWong, WK=8835876000en_HK
dc.identifier.scopusauthoridChan, H=9235692400en_HK
dc.identifier.scopusauthoridLaw, MF=24177056300en_HK
dc.identifier.scopusauthoridLiu, HSY=26024250200en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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