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Article: Clinical and endoscopic characteristics of non-Helicobacter pylori, non-NSAID duodenal ulcers: A long-term prospective study

TitleClinical and endoscopic characteristics of non-Helicobacter pylori, non-NSAID duodenal ulcers: A long-term prospective study
Authors
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2001, v. 15 n. 12, p. 1875-1882 How to Cite?
AbstractBackground: The proportion of duodenal ulcers not associated with Helicobacter pylori infection or the use of non-steroidal anti-inflammatory drugs (NSAIDs) is increasing. Aim: To identify the clinical and endoscopic characteristics of non-H. pylori, non-NSAID duodenal ulcers. Methods: Clinical and endoscopic data and H. pylori status were prospectively collected from consecutive patients who underwent upper endoscopy from 1997 to 1999. Patients with duodenal ulcers were identified, and those with non-H. pylori, non-NSAID duodenal ulcers were analysed further. Results: A total of 11 717 upper endoscopies were performed in 8344 patients. Of these, 1153 (14%) had duodenal ulcers. Of 599 patients with active ulcers and known H. pylori status. 104 (17%) had ulcers not associated with H. pylori or the use of NSAIDs, 393 (66%) had ulcers associated with H. pylori alone, 51 (8.5%) had ulcers associated with the use of NSAIDs alone and 51 (8.5%) had ulcers associated with both. Multivariate logistic regression analysis revealed that the presence of concomitant diseases (odds ratio = 15.0; 95% confidence interval, 8.64-25.9; P < 0.001) and the absence of epigastric pain/discomfort (odds ratio = 0.52; 95% confidence interval, 0.29-0.91: P = 0.022) were independent predictors for non-H. pylori, non-NSAID duodenal ulcers. Conclusions: Non-H. pylori, non-NSAID duodenal ulcers exhibit certain distinct clinical and endoscopic characteristics. The presence of concomitant diseases is an important predictive factor.
Persistent Identifierhttp://hdl.handle.net/10722/76456
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorWong, KWen_HK
dc.contributor.authorWong, SYen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorHu, WHCen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:21:26Z-
dc.date.available2010-09-06T07:21:26Z-
dc.date.issued2001en_HK
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2001, v. 15 n. 12, p. 1875-1882en_HK
dc.identifier.issn0269-2813en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76456-
dc.description.abstractBackground: The proportion of duodenal ulcers not associated with Helicobacter pylori infection or the use of non-steroidal anti-inflammatory drugs (NSAIDs) is increasing. Aim: To identify the clinical and endoscopic characteristics of non-H. pylori, non-NSAID duodenal ulcers. Methods: Clinical and endoscopic data and H. pylori status were prospectively collected from consecutive patients who underwent upper endoscopy from 1997 to 1999. Patients with duodenal ulcers were identified, and those with non-H. pylori, non-NSAID duodenal ulcers were analysed further. Results: A total of 11 717 upper endoscopies were performed in 8344 patients. Of these, 1153 (14%) had duodenal ulcers. Of 599 patients with active ulcers and known H. pylori status. 104 (17%) had ulcers not associated with H. pylori or the use of NSAIDs, 393 (66%) had ulcers associated with H. pylori alone, 51 (8.5%) had ulcers associated with the use of NSAIDs alone and 51 (8.5%) had ulcers associated with both. Multivariate logistic regression analysis revealed that the presence of concomitant diseases (odds ratio = 15.0; 95% confidence interval, 8.64-25.9; P < 0.001) and the absence of epigastric pain/discomfort (odds ratio = 0.52; 95% confidence interval, 0.29-0.91: P = 0.022) were independent predictors for non-H. pylori, non-NSAID duodenal ulcers. Conclusions: Non-H. pylori, non-NSAID duodenal ulcers exhibit certain distinct clinical and endoscopic characteristics. The presence of concomitant diseases is an important predictive factor.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_HK
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_HK
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - therapeutic useen_HK
dc.subject.meshChronic Diseaseen_HK
dc.subject.meshDuodenal Ulcer - drug therapy - epidemiology - microbiologyen_HK
dc.subject.meshEndoscopy, Gastrointestinalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHelicobacter Infections - drug therapy - epidemiology - microbiologyen_HK
dc.subject.meshHelicobacter pylori - isolation & purificationen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshQuestionnairesen_HK
dc.titleClinical and endoscopic characteristics of non-Helicobacter pylori, non-NSAID duodenal ulcers: A long-term prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-2813&volume=15&issue=12&spage=1875&epage=1882&date=2001&atitle=Clinical+and+endoscopic+characteristics+of+non-Helicobacter+pylori,+non-NSAID+duodenal+ulcers:+a+long-term+prospective+studyen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1046/j.1365-2036.2001.01115.xen_HK
dc.identifier.pmid11736717-
dc.identifier.scopuseid_2-s2.0-0035659139en_HK
dc.identifier.hkuros72112en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035659139&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1875en_HK
dc.identifier.epage1882en_HK
dc.identifier.isiWOS:000172788300005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXia, HHX=8757161400en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridWong, KW=35118458300en_HK
dc.identifier.scopusauthoridWong, SY=7404590845en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridHu, WHC=25932937100en_HK
dc.identifier.scopusauthoridChan, CK=7404813960en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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